Influenza (the flu) virus infections - Explained by Dr. Yeung Ho Hong(楊浩康)
Antiviral agents for influenza are medications used to treat or prevent influenza (the flu) virus infections. Here are the main categories and examples:
1. Neuraminidase Inhibitors
These drugs inhibit the neuraminidase enzyme, which is essential for the virus's replication and spread.
- *Oseltamivir (Tamiflu)*: Administered orally, effective for treating and preventing influenza.
- *Zanamivir (Relenza)*: Administered via inhalation, used for treatment and prevention.
- *Peramivir (Rapivab)*: A single intravenous dose for treatment in severe cases.
2. Polymerase Inhibitors
These agents inhibit viral RNA polymerase, affecting viral replication.
- *Baloxavir marboxil (Xofluza)*: A newer medication given as a single dose, effective against influenza A and B.
3. Adamantanes
These are older antiviral drugs that target the M2 protein of the virus.
- *Amantadine* and *Rimantadine*: Primarily effective against influenza A; however, many strains have developed resistance, so they are less commonly used.
Usage Guidelines
- *Timing*: Antivirals are most effective when started within 48 hours of symptom onset.
- *Prophylaxis*: Can be used in individuals at high risk of complications or during outbreaks.
Side Effects
- Common side effects include nausea and vomiting, especially with oseltamivir.
- Zanamivir may cause respiratory issues in individuals with asthma or chronic obstructive pulmonary disease (COPD).
Recommendations
- Vaccination remains the primary method of prevention against influenza.
- Antivirals are a supplemental measure, particularly for high-risk populations or during severe outbreaks.
If you have specific questions about a particular antiviral or its use, Your doctor will help you solve your problem!